An actual-world examine of sufferers with a number of myeloma (MM) in the US discovered that coronary heart assault and stroke dangers are considerably greater on this affected person inhabitants in contrast with the overall inhabitants. The findings have been introduced as an summary on the sixty fourth American Society of Hematology Annual Assembly and Exposition held in New Orleans, Louisiana.
Sufferers with MM are at an elevated threat of arterial and venous thrombosis, however there’s a lack of real-world research exploring the affiliation between MM and arterial thrombosis in the US. The retrospective examine aimed to characterize the danger of stroke and coronary heart assault on this affected person inhabitants utilizing a database of affected person information spanning 26 well being care techniques in 50 states (IBM Explorys).
Intercourse, age (older than 65 years), hypertension, hyperlipidemia, diabetes, smoking standing, and atrial fibrillation have been additionally evaluated as threat elements for coronary heart assault and stroke within the examine. A multivariable logistic regression factoring in these covariates was carried out to find out the associations between MM and coronary heart assault, in addition to stroke.
A complete of 70,434,190 sufferers have been included within the cohort, 67,920 of whom have been recognized with MM between 1999 and 2022. Most sufferers (77%) have been older than 65 years and 52% have been males. Concerning comorbidities, 19% of sufferers within the cohort have been overweight, 67% had hypertension, 53% had hyperlipidemia, 31% had diabetes, and 21% had atrial fibrillation.
Within the MM cohort, 600 sufferers skilled a stroke and 5370 skilled a coronary heart assault (0.88% and seven.9% of the MM group, respectively). The chance of stroke was considerably greater within the MM group in contrast with sufferers who didn’t have MM, even after adjusting for confounding threat elements (odds ratio [OR], 1.51; 95% CI, 1.43-1.59). Sufferers with MM have been additionally extra prone to expertise a coronary heart assault in contrast with the overall inhabitants (OR, 1.36; 95% CI, 1.32-1.39).
The examine is the most important real-world evaluation of arterial thrombotic occasions amongst sufferers with MM in the US. General, people with MM have been 51% extra prone to have a stroke and 36% extra prone to have a coronary heart assault in contrast with sufferers who didn’t have MM. Nonetheless, additional analysis is required to establish at-risk people and to threat stratify these sufferers. “Given the enormity of the danger, physicians ought to take into account optimizing modifiable threat elements in all sufferers with a number of myeloma,” the authors concluded.
Al Armashi AR, Elantably D, Wang J, Al Zubaidi A, Alkrekshi A. The chance of stroke and myocardial infarction in a number of myeloma: a population-based examine in the US. Introduced at: sixty fourth American Society of Hematology Annual Assembly and Exposition; New Orleans, LA; December 10-13, 2022; Summary 3215. Accessed December 17, 2022. https://ash.confex.com/ash/2022/webprogram/Paper166847.html